Olfactory sensory experience regulates gliomagenesis via neuronal IGF1


  • Louis, D. N. et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a abstract. Neuro-Oncol. 23, 1231–1251 (2021).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Venkatesh, H. S. et al. Electrical and synaptic integration of glioma into neural circuits. Nature 573, 539–545 (2019).

    ADS 
    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Venkataramani, V. et al. Glutamatergic synaptic enter to glioma cells drives mind tumour development. Nature 573, 532–538 (2019).

    ADS 
    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Alcantara Llaguno, S. R. et al. Grownup lineage-restricted CNS progenitors specify distinct glioblastoma subtypes. Most cancers Cell 28, 429–440 (2015).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Galvao, R. P. et al. Transformation of quiescent grownup oligodendrocyte precursor cells into malignant glioma by means of a multistep reactivation course of. Proc. Natl Acad. Sci. USA 111, E4214–4223 (2014).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Tian, A. et al. Oncogenic state and cell identification combinatorially dictate the susceptibility of cells inside glioma improvement hierarchy to IGF1R focusing on. Adv. Sci. 7, 2001724 (2020).

    CAS 
    Article 

    Google Scholar 

  • Quail, D. F. & Joyce, J. A. The microenvironmental panorama of mind tumors. Most cancers Cell 31, 326–341 (2017).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Monje, M. et al. Roadmap for the rising area of most cancers neuroscience. Cell 181, 219–222 (2020).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Peterson, S. C. et al. Basal cell carcinoma preferentially arises from stem cells inside hair follicle and mechanosensory niches. Cell Stem Cell 16, 400–412 (2015).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Magnon, C. et al. Autonomic nerve improvement contributes to prostate most cancers development. Science 341, 1236361 (2013).

    PubMed 
    Article 

    Google Scholar 

  • Renz, B. W. et al. β2 adrenergic–neurotrophin feedforward loop promotes pancreatic most cancers. Most cancers Cell 33, 75–90 (2018).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Hayakawa, Y. et al. Nerve development issue promotes gastric tumorigenesis by means of aberrant cholinergic signaling. Most cancers Cell 31, 21–34 (2017).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Zeng, Q. et al. Synaptic proximity allows NMDAR signalling to advertise mind metastasis. Nature 573, 526–531 (2019).

    ADS 
    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Zahalka, A. H. & Frenette, P. S. Nerves in most cancers. Nat. Rev. Most cancers 20, 143–157 (2020).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Larjavaara, S. et al. Incidence of gliomas by anatomic location. Neuro-Oncol. 9, 319–325 (2007).

    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Ellingson, B. M. et al. Probabilistic radiographic atlas of glioblastoma phenotypes. Am. J. Neuroradiol. 34, 533–540 (2013).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Uchida, N., Poo, C. & Haddad, R. Coding and transformations within the olfactory system. Annu. Rev. Neurosci. 37, 363–385 (2014).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Komiyama, T. & Luo, L. Improvement of wiring specificity within the olfactory system. Curr. Opin. Neurobiol. 16, 67–73 (2006).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Kikuta, S. et al. Sensory deprivation disrupts homeostatic regeneration of newly generated olfactory sensory neurons after harm in grownup mice. J. Neurosci. 35, 2657–2673 (2015).

    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S. & Roth, B. L. Evolving the lock to suit the important thing to create a household of G protein-coupled receptors potently activated by an inert ligand. Proc. Natl Acad. Sci. USA 104, 5163–5168 (2007).

    ADS 
    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar 

  • Farbman, A. I. & Margolis, F. L. Olfactory marker protein throughout ontogeny: immunohistochemical localization. Dev. Biol. 74, 205–215 (1980).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Gomez, J. L. et al. Chemogenetics revealed: DREADD occupancy and activation by way of transformed clozapine. Science 357, 503–507 (2017).

    ADS 
    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Kato, H. Ok., Chu, M. W., Isaacson, J. S. & Komiyama, T. Dynamic sensory representations within the olfactory bulb: modulation by wakefulness and expertise. Neuron 76, 962–975 (2012).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Baker, H., Morel, Ok., Stone, D. M. & Maruniak, J. A. Grownup naris closure profoundly reduces tyrosine hydroxylase expression in mouse olfactory bulb. Mind Res. 614, 109–116 (1993).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Cao, P., Maximov, A. & Sudhof, T. C. Exercise-dependent IGF-1 exocytosis is managed by the Ca2+-sensor synaptotagmin-10. Cell 145, 300–311 (2011).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Mesik, L. et al. Practical response properties of VIP-expressing inhibitory neurons in mouse visible and auditory cortex. Entrance. Neural Circuits 9, 22 (2015).

    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Quail, D. F. et al. The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science 352, aad3018 (2016).

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar 

  • Yao, M. et al. Astrocytic trans-differentiation completes a multicellular paracrine suggestions loop required for medulloblastoma tumor development. Cell 180, 502–520 (2020).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Myhre, C. L. et al. Microglia specific insulin-like development factor-1 within the hippocampus of aged APPswe/PS1ΔE9 transgenic mice. Entrance. Cell. Neurosci. 13, 308 (2019).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Ueno, M. et al. Layer V cortical neurons require microglial assist for survival throughout postnatal improvement. Nat. Neurosci. 16, 543–551 (2013).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Hammond, T. R. et al. Single-cell RNA sequencing of microglia all through the mouse lifespan and within the injured mind reveals complicated cell-state modifications. Immunity 50, 253–271 (2019).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Zong, H., Espinosa, J. S., Su, H. H., Muzumdar, M. D. & Luo, L. Mosaic evaluation with double markers in mice. Cell 121, 479–492 (2005).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Liu, C. et al. Mosaic evaluation with double markers reveals tumor cell of origin in glioma. Cell 146, 209–221 (2011).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Henner, A., Ventura, P. B., Jiang, Y. & Zong, H. MADM-ML, a mouse genetic mosaic system with elevated clonal effectivity. PLoS ONE 8, e77672 (2013).

    ADS 
    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Liu, T. T. et al. Computational identification of tumor anatomic location related to survival in 2 giant cohorts of human main glioblastomas. Am. J. Neuroradiol. 37, 621–628 (2016).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Itakura, H. et al. Magnetic resonance picture options determine glioblastoma phenotypic subtypes with distinct molecular pathway actions. Sci. Transl. Med. 7, 303ra138 (2015).

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar 

  • Zlatescu, M. C. et al. Tumor location and development sample correlate with genetic signature in oligodendroglial neoplasms. Most cancers Res. 61, 6713–6715 (2001).

    CAS 
    PubMed 

    Google Scholar 

  • McGann, J. P. Poor human olfaction is a Nineteenth-century delusion. Science 356, eaam7263 (2017).

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar 

  • Murillo-Cuesta, S., Rodriguez-de la Rosa, L., Cediel, R., Lassaletta, L. & Varela-Nieto, I. The position of insulin-like development factor-I within the physiopathology of listening to. Entrance. Mol. Neurosci. 4, 11 (2011).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Mardinly, A. R. et al. Sensory expertise regulates cortical inhibition by inducing IGF1 in VIP neurons. Nature 531, 371–375 (2016).

    ADS 
    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Jing, D. et al. Tissue clearing of each laborious and delicate tissue organs with the PEGASOS methodology. Cell Res. 28, 803–818 (2018).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Yang, M. & Crawley, J. N. Easy behavioral evaluation of mouse olfaction. Curr. Protoc. Neurosci. 48, 8.24.1–8.24.12 (2009).

    Google Scholar 

  • Ludewig, P. et al. Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits MMP-9-mediated blood-brain-barrier breakdown in a mouse mannequin for ischemic stroke. Circ. Res. 113, 1013–1022 (2013).

    CAS 
    PubMed 
    Article 

    Google Scholar 

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