Pluvinage, J. V. & Wyss-Coray, T. Systemic elements as mediators of mind homeostasis, ageing and neurodegeneration. Nat. Rev. Neurosci. 21, 93–102 (2020).

CAS 
PubMed 
Article 

Google Scholar 

Castellano, J. M. et al. Human umbilical twine plasma proteins revitalize hippocampal operate in aged mice. Nature 544, 488–492 (2017).

ADS 
CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Villeda, S. A. et al. Younger blood reverses age-related impairments in cognitive operate and synaptic plasticity in mice. Nat. Med. 20, 659–663 (2014).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Lehtinen, M. Okay. et al. The cerebrospinal fluid offers a proliferative area of interest for neural progenitor cells. Neuron 69, 893–905 (2011).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Silva-Vargas, V., Maldonado-Soto, A. R., Mizrak, D., Codega, P. & Doetsch, F. Age-dependent area of interest indicators from the choroid plexus regulate grownup neural stem cells. Cell Stem Cell 19, 643–652 (2016).

CAS 
PubMed 
Article 

Google Scholar 

Fame, R. M. & Lehtinen, M. Okay. Emergence and developmental roles of the cerebrospinal fluid system. Dev. Cell 52, 261–275 (2020).

CAS 
PubMed 
Article 

Google Scholar 

Chen, C. P., Chen, R. L. & Preston, J. E. The affect of ageing within the cerebrospinal fluid concentrations of proteins which can be derived from the choroid plexus, mind, and plasma. Exp. Gerontol. 47, 323–328 (2012).

CAS 
PubMed 
Article 

Google Scholar 

Baird, G. S. et al. Age-dependent adjustments within the cerebrospinal fluid proteome by sluggish off-rate modified aptamer array. Am. J. Pathol. 180, 446–456 (2012).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Li, G. et al. Cerebrospinal fluid focus of brain-derived neurotrophic issue and cognitive operate in non-demented topics. PLoS ONE 4, e5424 (2009).

ADS 
PubMed 
PubMed Central 
Article 
CAS 

Google Scholar 

Pan, S., Mayoral, S. R., Choi, H. S., Chan, J. R. & Kheirbek, M. A. Preservation of a distant worry reminiscence requires new myelin formation. Nat. Neurosci. 23, 487–499 (2020).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Vetere, G. et al. Chemogenetic interrogation of a brain-wide worry reminiscence community in mice. Neuron 94, 363–374 (2017).

CAS 
PubMed 
Article 

Google Scholar 

Fogel, S. M. et al. fMRI and sleep correlates of the age-related impairment in motor reminiscence consolidation. Hum. Mind Mapp. 35, 3625–3645 (2014).

PubMed 
Article 

Google Scholar 

Gibson, E. M. et al. Neuronal exercise promotes oligodendrogenesis and adaptive myelination within the mammalian mind. Science 344, 1252304 (2014).

PubMed 
PubMed Central 
Article 
CAS 

Google Scholar 

Dugas, J. C. & Emery, B. Purification of oligodendrocyte precursor cells from rat cortices by immunopanning. Chilly Spring Harb. Protoc. 2013, 745–758 (2013).

PubMed 

Google Scholar 

Solar, L. O. et al. Spatiotemporal management of CNS myelination by oligodendrocyte programmed cell dying by the TFEB–PUMA axis. Cell 175, 1811–1826 (2018).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Zuchero, J. B. et al. CNS myelin wrapping is pushed by actin disassembly. Dev. Cell 34, 152–167 (2015).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Schwarz, N. et al. Human cerebrospinal fluid promotes long-term neuronal viability and community operate in human neocortical organotypic mind slice cultures. Sci. Rep. 7, 12249 (2017).

ADS 
PubMed 
PubMed Central 
Article 
CAS 

Google Scholar 

Wentling, M. et al. A metabolic perspective on CSF-mediated neurodegeneration in a number of sclerosis. Mind 142, 2756–2774 (2019).

PubMed 
Article 

Google Scholar 

Mathur, D. et al. Bioenergetic failure in rat oligodendrocyte progenitor cells handled with cerebrospinal fluid derived from a number of sclerosis sufferers. Entrance. Cell. Neurosci. 11, 209 (2017).

PubMed 
PubMed Central 
Article 
CAS 

Google Scholar 

Braun, T. & Gautel, M. Transcriptional mechanisms regulating skeletal muscle differentiation, development and homeostasis. Nat. Rev. Mol. Cell Biol. 12, 349–361 (2011).

CAS 
PubMed 
Article 

Google Scholar 

Guo, Y. et al. Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response issue. Nat. Commun. 9, 3837 (2018).

ADS 
PubMed 
PubMed Central 
Article 
CAS 

Google Scholar 

Knoll, B. & Nordheim, A. Purposeful versatility of transcription elements within the nervous system: the SRF paradigm. Traits Neurosci. 32, 432–442 (2009).

PubMed 
Article 
CAS 

Google Scholar 

Miralles, F., Posern, G., Zaromytidou, A. I. & Treisman, R. Actin dynamics management SRF exercise by regulation of its coactivator MAL. Cell 113, 329–342 (2003).

CAS 
PubMed 
Article 

Google Scholar 

Knoll, B. et al. Serum response issue controls neuronal circuit meeting within the hippocampus. Nat. Neurosci. 9, 195–204 (2006).

PubMed 
Article 
CAS 

Google Scholar 

Lahoute, C. et al. Untimely ageing in skeletal muscle missing serum response issue. PLoS ONE 3, e3910 (2008).

ADS 
PubMed 
PubMed Central 
Article 
CAS 

Google Scholar 

Mergoud Dit Lamarche, A. et al. UNC-120/SRF independently controls muscle ageing and lifespan in Caenorhabditis elegans. Getting older Cell 17, e12713 (2018).

PubMed Central 
Article 
CAS 

Google Scholar 

Ximerakis, M. et al. Single-cell transcriptomic profiling of the ageing mouse mind. Nat. Neurosci. 22, 1696–1708 (2019).

CAS 
PubMed 
Article 

Google Scholar 

Falcao, A. M. et al. Illness-specific oligodendrocyte lineage cells come up in a number of sclerosis. Nat. Med. 24, 1837–1844 (2018).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Iacono, G., Altafini, C. & Torre, V. Early part of plasticity-related gene regulation and SRF dependent transcription within the hippocampus. PLoS ONE 8, e68078 (2013).

ADS 
CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Kuzniewska, B. et al. Mind-derived neurotrophic issue induces matrix metalloproteinase 9 expression in neurons through the serum response issue/c-Fos pathway. Mol. Cell. Biol. 33, 2149–2162 (2013).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Sasayama, D. et al. Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome. Hum. Mol. Genet. 26, 44–51 (2017).

CAS 
PubMed 

Google Scholar 

Sathyan, S. et al. Plasma proteomic profile of age, well being span, and all-cause mortality in older adults. Getting older Cell 19, e13250 (2020).

CAS 
PubMed 
PubMed Central 

Google Scholar 

Esnault, C. et al. Rho–actin signaling to the MRTF coactivators dominates the fast transcriptional response to serum in fibroblasts. Genes Dev. 28, 943–958 (2014).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Fortin, D., Rom, E., Solar, H., Yayon, A. & Bansal, R. Distinct fibroblast development issue (FGF)/FGF receptor signaling pairs provoke numerous mobile responses within the oligodendrocyte lineage. J. Neurosci. 25, 7470–7479 (2005).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Ramanan, N. et al. SRF mediates activity-induced gene expression and synaptic plasticity however not neuronal viability. Nat. Neurosci. 8, 759–767 (2005).

CAS 
PubMed 
Article 

Google Scholar 

Etkin, A. et al. A task in studying for SRF: deletion within the grownup forebrain disrupts LTD and the formation of a direct reminiscence of a novel context. Neuron 50, 127–143 (2006).

CAS 
PubMed 
Article 

Google Scholar 

Pan, S., Mayoral, S. R., Choi, H. S., Chan, J. R. & Kheirbek, M. A. Preservation of a distant worry reminiscence requires new myelin formation. Nat. Neurosci. 23, 487–499 (2020).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Xiao, L. et al. Fast manufacturing of latest oligodendrocytes is required within the earliest levels of motor-skill studying. Nat. Neurosci. 19, 1210–1217 (2016).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Steadman, P. E. et al. Disruption of oligodendrogenesis impairs reminiscence consolidation in grownup mice. Neuron 105, 150–164 (2020).

CAS 
PubMed 
Article 

Google Scholar 

Wang, F. et al. Myelin degeneration and diminished myelin renewal contribute to age-related deficits in reminiscence. Nat. Neurosci. 23, 481–486 (2020).

PubMed 
PubMed Central 
Article 
CAS 

Google Scholar 

Chen, J. F. et al. Enhancing myelin renewal reverses cognitive dysfunction in a murine mannequin of Alzheimer’s illness. Neuron 109, 2292–2307 (2021).

CAS 
PubMed 
Article 

Google Scholar 

Segel, M. et al. Area of interest stiffness underlies the ageing of central nervous system progenitor cells. Nature 573, 130–134 (2019).

ADS 
CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Neumann, B. et al. Metformin restores CNS remyelination capability by rejuvenating aged stem cells. Cell Stem Cell 25, 473–485 (2019).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Bonetto, G., Belin, D. & Karadottir, R. T. Myelin: a gatekeeper of activity-dependent circuit plasticity? Science 374, eaba6905 (2021).

PubMed 
Article 
CAS 

Google Scholar 

Xu, J., Liu, Z. & Ornitz, D. M. Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar buildings. Improvement 127, 1833–1843 (2000).

CAS 
PubMed 
Article 

Google Scholar 

Furusho, M., Ishii, A., Hebert, J. M. & Bansal, R. Developmental stage-specific position of Frs adapters as mediators of FGF receptor signaling within the oligodendrocyte lineage cells. Glia 68, 617–630 (2020).

PubMed 
Article 

Google Scholar 

Oh, L. Y. et al. Fibroblast development issue receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiation. J. Neurosci. 23, 883–894 (2003).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Kang, W., Nguyen, Okay. C. Q. & Hebert, J. M. Transient redirection of SVZ stem cells to oligodendrogenesis by FGFR3 activation promotes remyelination. Stem Cell Rep. 12, 1223–1231 (2019).

CAS 
Article 

Google Scholar 

Jen, Y. H., Musacchio, M. & Lander, A. D. Glypican-1 controls mind measurement by regulation of fibroblast development issue signaling in early neurogenesis. Neural Dev. 4, 33 (2009).

PubMed 
PubMed Central 
Article 
CAS 

Google Scholar 

Scearce-Levie, Okay. et al. Irregular social behaviors in mice missing Fgf17. Genes Mind Behav. 7, 344–354 (2008).

CAS 
PubMed 
Article 

Google Scholar 

De Miguel, Z. et al. Train plasma boosts reminiscence and dampens mind irritation through clusterin. Nature 600, 494–499 (2021).

ADS 
PubMed 
Article 
CAS 

Google Scholar 

Liu, L. & Duff, Okay. A way for serial assortment of cerebrospinal fluid from the cisterna magna in mouse. J. Vis. Exp. https://doi.org/10.3791/960 (2008).

Smith, A., Wu, A. H., Lynch, Okay. L., Ko, N. & Grenache, D. G. Multi-wavelength spectrophotometric evaluation for detection of xanthochromia in cerebrospinal fluid and accuracy for the analysis of subarachnoid hemorrhage. Clin. Chim. Acta 424, 231–236 (2013).

CAS 
PubMed 
Article 

Google Scholar 

Olsson, M., Arlig, J., Hedner, J., Blennow, Okay. & Zetterberg, H. Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer’s illness. Sleep https://doi.org/10.1093/sleep/zsy025 (2018).

Olsson, M., Arlig, J., Hedner, J., Blennow, Okay. & Zetterberg, H. Sleep deprivation and plasma biomarkers for Alzheimer’s illness. Sleep Med. 57, 92–93 (2019).

PubMed 
Article 

Google Scholar 

Lynch, H. J., Rivest, R. W. & Wurtman, R. J. Synthetic induction of melatonin rhythms by programmed microinfusion. Neuroendocrinology 31, 106–111 (1980).

CAS 
PubMed 
Article 

Google Scholar 

Pluvinage, J. V. et al. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature 568, 187–192 (2019).

ADS 
CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Lukinavicius, G. et al. Fluorogenic probes for live-cell imaging of the cytoskeleton. Nat. Strategies 11, 731–733 (2014).

CAS 
PubMed 
Article 

Google Scholar 

Friedman, P. L. & Ellisman, M. H. Enhanced visualization of peripheral nerve and sensory receptors within the scanning electron microscope utilizing cryofracture and osmium–thiocarbohydrazide–osmium impregnation. J. Neurocytol. 10, 111–131 (1981).

CAS 
PubMed 
Article 

Google Scholar 

Willingham, M. C. & Rutherford, A. V. The usage of osmium–thiocarbohydrazide–osmium (OTO) and ferrocyanide-reduced osmium strategies to reinforce membrane distinction and preservation in cultured cells. J. Histochem. Cytochem. 32, 455–460 (1984).

CAS 
PubMed 
Article 

Google Scholar 

Ewald, A. J. et al. Mammary collective cell migration entails transient lack of epithelial options and particular person cell migration inside the epithelium. J. Cell Sci. 125, 2638–2654 (2012).

CAS 
PubMed 
PubMed Central 

Google Scholar 

McDonald, Okay. L. & Webb, R. I. Freeze substitution in 3 hours or much less. J. Microsc. 243, 227–233 (2011).

CAS 
PubMed 
Article 

Google Scholar 

Emery, B. & Dugas, J. C. Purification of oligodendrocyte lineage cells from mouse cortices by immunopanning. Chilly Spring Harb. Protoc. 2013, 854–868 (2013).

PubMed 
Article 

Google Scholar 

Muhar, M. et al. SLAM-seq defines direct gene-regulatory capabilities of the BRD4–MYC axis. Science 360, 800–805 (2018).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Stockel, D. et al. Multi-omics enrichment evaluation utilizing the GeneTrail2 net service. Bioinformatics 32, 1502–1508 (2016).

PubMed 
Article 
CAS 

Google Scholar 

Hahn, O. et al. CoolMPS for strong sequencing of single-nuclear RNAs captured by droplet-based technique. Nucleic Acids Res. 49, e11 (2021).

CAS 
PubMed 
Article 

Google Scholar 

Newman, A. M. et al. Figuring out cell sort abundance and expression from bulk tissues with digital cytometry. Nat. Biotechnol. 37, 773–782 (2019).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Steen, C. B., Liu, C. L., Alizadeh, A. A. & Newman, A. M. Profiling cell sort abundance and expression in bulk tissues with CIBERSORTx. Strategies Mol. Biol. 2117, 135–157 (2020).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Wolf, F. A., Angerer, P. & Theis, F. J. SCANPY: large-scale single-cell gene expression knowledge evaluation. Genome Biol. 19, 15 (2018).

PubMed 
PubMed Central 
Article 

Google Scholar 

Schaum, N. et al. Ageing hallmarks exhibit organ-specific temporal signatures. Nature 583, 596–602 (2020).

ADS 
CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Spitzer, S. O. et al. Oligodendrocyte progenitor cells grow to be regionally numerous and heterogeneous with age. Neuron 101, 459–471 (2019).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Mathys, H. et al. Single-cell transcriptomic evaluation of Alzheimer’s illness. Nature 570, 332–337 (2019).

ADS 
CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

Zhou, Y. et al. Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent mobile responses in Alzheimer’s illness. Nat. Med. 26, 131–142 (2020).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar 

The Tabula Muris Consortium. A single-cell transcriptomic atlas characterizes ageing tissues within the mouse. Nature 583, 590–595 (2020).

Matys, V. et al. TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes. Nucleic Acids Res. 34, D108–D110 (2006).

ADS 
CAS 
PubMed 
Article 

Google Scholar 

Gerstner, N. et al. GeneTrail 3: superior high-throughput enrichment evaluation. Nucleic Acids Res. 48, W515–W520 (2020).

CAS 
PubMed 
PubMed Central 
Article 

Google Scholar